Posmodernsex
Man, 43y
43 years old, Man

GCS: future gene therapy that could turn testicles into ovaries and vice versa?Currently CRISPR (Gene knockout/introduction) is being approved for human testing. CRISPR is what is called a gene drive or gene “editor.” By introducing a gene known currently as CBX2 and theoretically FOXL2 and removing DMRT1, a study proved that in mice, ovaries could be converted to testes, while testes could be converted to ovaries.
FOXL2 is a gene that instructs ovarian tissue to STAY ovarian tissue and not convert to testicular tissue, whereas DMRT1 is the mirror opposite, instructing testicular tissue to remain tissue and not convert to ovarian tissue.
So in theory, by simply introducing this gene drive with the desired gene modifications, the drive would spread throughout the targeted tissue type and modify each cell, thus converting testes to ovarian tissue.

It means that instead of needing hormone replacement therapy drugs for the rest of their life, they would theoretically just relocate the gonadal tissue to a place appropriate for that tissue within the body and they would have their own hormone production congruent with their desired gender.

Also, this allows for modification of the XY chromosome to remove the SRY gene that prevents female development. Introducing this into bone marrow would in essence make creating a genetically matched vagina, uterus, and ovaries through 3d printing and lab construction. In theory, of course, this can all be done in the next five years if the scientific community targets this field for a major study. Problem is, funding for studies into transgender health and science is extremely difficult to procure, and thus are not typically considered important.
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Gender: Man

Age: 43 years old

Country: Brazil

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Region: Minas Gerais

City: Belo horizonte

Languages: English, Español, Italiano, Português

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Seeking: Woman, Man, Couple, Gay man, Gay couple, Lesbian woman, Transsexual

Religion: Atheist

Signed up: February 3, 2015 (3,626 days ago)

Last activity: 3 days ago

Contact: Chat with Posmodernsex

About me:

GCS: future gene therapy that could turn testicles into ovaries and vice versa?Currently CRISPR (Gene knockout/introduction) is being approved for human testing. CRISPR is what is called a gene drive or gene “editor.” By introducing a gene known currently as CBX2 and theoretically FOXL2 and removing DMRT1, a study proved that in mice, ovaries could be converted to testes, while testes could be converted to ovaries.
FOXL2 is a gene that instructs ovarian tissue to STAY ovarian tissue and not convert to testicular tissue, whereas DMRT1 is the mirror opposite, instructing testicular tissue to remain tissue and not convert to ovarian tissue.
So in theory, by simply introducing this gene drive with the desired gene modifications, the drive would spread throughout the targeted tissue type and modify each cell, thus converting testes to ovarian tissue.

It means that instead of needing hormone replacement therapy drugs for the rest of their life, they would theoretically just relocate the gonadal tissue to a place appropriate for that tissue within the body and they would have their own hormone production congruent with their desired gender.

Also, this allows for modification of the XY chromosome to remove the SRY gene that prevents female development. Introducing this into bone marrow would in essence make creating a genetically matched vagina, uterus, and ovaries through 3d printing and lab construction. In theory, of course, this can all be done in the next five years if the scientific community targets this field for a major study. Problem is, funding for studies into transgender health and science is extremely difficult to procure, and thus are not typically considered important.Show more